Sjögren’s disease is a systemic disorder in which its defining clinical features, dryness of the eyes and mouth, arise from an autoimmune process impairing lacrimal and salivary gland function. It may occur either alone or in the context of another autoimmune disease, such as rheumatoid arthritis or systemic lupus erythematosus. Sjögren’s disease is one of the most prevalent systemic autoimmune rheumatic diseases with a unique predilection for post-menopausal women. The disease may affect the nervous system, lungs, and kidneys in addition to the exocrine glands. Chronic fatigue, joint pain, and neuropathic pain are significant sources of disability. Late complications may include corneal ulceration, advanced dental decay, and non-Hodgkin lymphoma.
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